But, for all the grief it’s causing, Protocol 321 may be the least of Upjohn’s problems. Far more critical to the U.S. Food and Drug Administration’s 1982 approval of Halcion was a clinical trial called Protocol 6045. Unlike Protocol 321, a six-week tolerance study conducted on 58 healthy prison inmates, Protocol 6045 included four 28-day studies involving 129 true insomniacs. It was the largest of three trials the FDA deemed “pivotal” to Halcion’s approval....
Dawson played a 14-year career with the Chiefs starting in 1962. The Purdue University graduate boasted a laundry list of achievements. Dawson led the Chiefs to the first-ever Super Bowl in 1967, in which they lost 35-10 to the Green Bay Packers. Dawson later led the Chiefs to their first Super Bowl title in 1970 against the Minnesota Vikings. Topping the list of his many achievements, Dawson was named to the Pro Football Hall of Fame in 1987....
The best horror films on Hulu this Halloween Blade Nearly two decades before Black Panther brought Black superhero fans a cool super of their own, they had Wesley Snipes’ Blade, the vampire-slaying vampire. Mahershala Ali is set to bring the character into the Marvel Cinematic Universe in the coming years, but he has big boots to fill from this original, which as Marvel’s first box office success is in some way responsible for cinema as we know it today....
First…You MUST Prepare Your Pumpkin Whatever your chosen design, prepping your pumpkin is the first step. Once you’ve chosen your favorite at the local pumpkin patch or store, get it home and get started. Using a sharp knife, carefully cut off the top of your pumpkin and remove the lid. Remember to cut your lid large enough to get inside and scoop out the insides, and keep it safe so you can replace it later....
Israel’s military issued a warning before obliterating the al-Jalaa Building, that was also a residential tower, on Saturday which provided for everyone inside to evacuate. Hamdan asserted that there was no Hamas military presence or armed group inside. “This is something we actively check to the best of our ability,” Associated Press President and CEO Gary Pruitt stated, while saying that his organization had no knowledge of Hamas presence in the Gaza building....
The Maestro passed away on July 6 in his home city of Rome, Italy after complications following a fall. He was 91 years old. Fellow composer Hans Zimmer has spoken of Morricone’s influence on film soundtracks during an appearance on British breakfast television show, BBC Breakfast. “Ennio was an icon and icons just don’t go away, icons are forever,” the Lion King and Gladiator composer said. “It really has taken me by surprise as he was still touring....
Sanchez has cut an increasingly frustrated figure at the Emirates Stadium over the past year and has allowed his contract to run into its final season. Alexis 10/11 to score v Burnley A deadline-day move to Manchester City fell through in August, reportedly to the Chile international’s dismay, and failure to qualify for the World Cup has done little to lift Sanchez’s mood. The attacker looked revived somewhat on Saturday, scoring in the Gunners’ impressive 2-0 win over north London rivals Tottenham....
The Stars registered a 1-1 draw against Uganda on Thursday without some of their key players like Captain Victor Wanyama and it is expected that Okumbi will launch a complete arsenal against The Leopards in search of a win. Kenya won 1-0 in their last meeting and the coach believes that his side has what it takes to replicate the October 2016 result. “We have beaten them before so why shouldn’t we do the same once more?...
Now, he’s upset a fifth-year senior. MORE: Michigan’s tough non-con schedule | Former player calls Harbaugh ‘crazy’ | Preseason All-Americans Harbaugh told every fifth-year player they would have to try out during spring practice to remain on the team, according to the Columbus Dispatch. Former tight end Keith Heitzman was one of those players and told the Dispatch he wasn’t happy about having to try out. “Obviously, Harbaugh coming in was going to change things at Michigan — do things his way,” said Heitzman....
Three months ago, when their 40-year-old colleague suddenly died of AIDS complications, workers at a small travel agency in San Francisco went into deep shock. It was Unravel Travel’s second death from AIDS and its fourth death in four years. Small groups of employees whispered in corners. Sharon Curtis, 47, found herself depressed by the new crop of sickness jokes and comments like “Who’s next?” The agency’s owner, Martha Nell Beatty, 57, became impatient with clients over “what suddenly seemed petty to me-complaints about getting an aisle seat instead of a window....
Stardust: Set to launch in early 1999, the craft will travel 242 million miles and fly through the path of Comet Wild-2. An arm, looking something like a giant fly swatter, will extend to capture icy dust and organic compounds from the comet and return them to Earth seven years later. Scientists believe that comets ma y have carried the building blocks of life to Earth billions of years ago; they hope to recover traces....
After processing from Westminster Hall, where the queen’s body had been lying-in-state, to Westminster Abbey, alongside his brother Prince William, Harry joined Meghan with other members of the royal family to take their seats at the foot of the high altar. Harry and Meghan were seated directly behind King Charles III and Queen Camilla, alongside their royal cousins, Princesses Beatrice and Eugenie, and Prince Edward and Sophie, Countess of Wessex....
Kane has been in lethal form so far this season, scoring 15 goals for club and country, including five in the Champions League, and he will undoubtedly be eager to inspire the downfall of Madrid at the Santiago Bernabeu on Tuesday. Kane 5/1 FGS with dabblebet The England international’s development into a world-class striker was seemingly evidenced by his nomination for the Ballon d’Or, with Kane impressing throughout 2017....
The eight films are currently streaming on HBO Max, but that is set to change thanks to a previous contract agreement made before Warner Bros launched its streaming service. This isn’t the first time the Harry Potter movies have left a streaming service. In fact, they have moved every few months since HBO Max’s launch in 2020. That’s in contrast to other films in the so-called “Wizarding World” franchise, which stays in one place while its older sister keeps moving around....
Lord Jeffrey Archer, the bestselling novelist and long-standing member of the Conservative party, has expressed his belief that the prince’s book stands a “50/50” chance of being “scrapped” as reports of tensions with the royal family over the project circulate. Harry announced his autobiographical project with Random House publishers in July 2021. In a statement at the time, he said: “I’m writing this not as the prince I was born but as the man I have become…I’m deeply grateful for the opportunity to share what I’ve learned over the course of my life so far and excited for people to read a firsthand account of my life that’s accurate and wholly truthful....
The “Watermelon Sugar” singer is set to star alongside Florence Pugh in the highly-anticipated psychological thriller directed by his current girlfriend Olivia Wilde. However, some of the excitement around the movie appears to be dissipating among some fans after a promotional clip was shared to social media of a scene featuring Styles and Pugh. The video was originally posted to the official Don’t Worry Darling Twitter account but was subsequently reposted by MovieRankings....
The 29-year-old moved to Serie A on a season-long loan deal after falling out of favor with City boss Pep Guardiola, who signed Claudio Bravo from Barcelona to replace him. Hart has had a mixed campaign in Italy, with some impressive displays against Empoli and Pescara undermined by crucial mistakes in defeats to Atalanta on his debut and Inter last Wednesday. Question marks remain over whether Hart will look to secure a permanent move away from the Etihad Stadium, but he insists that his focus for now is on helping Torino in its push for Europe....
At least two other U.S. universities received donations linked to Epstein, and neither has said it will return the gifts. A Harvard University spokesperson told Newsweek “the University has no plans to return the $6.5M to Epstein,” which the money manager donated in 2003. The Daily Beast reported earlier this year that the University of Arizona Foundation kept $50,000 received in 2017 from Gratitude America, Ltd, an organization where Epstein has served as president....
Now it’s time for the speech of his life. We’re not talking about delivering a great speech, just an appropriate one that accurately depicts the enormity of the moment. He’ll probably talk about family, as he credits the decision by himself and wife DeLana to close their race team, have a family and focus on life as a driver and a father instead of driver and team owner as pivotal to his career....
All fans should cherish Messi & Iniesta Hasenhuttl led Ingolstadt to the 2. Bundesliga title in 2014-15 and ended an impressive debut season in the top flight with a 10th-place finish. However, the Austrian moved to Leipzig ahead of the 2016-17 campaign and has helped launch a surprise bid to win the Bundesliga, with his team second to Bayern only due to an inferior goal difference. Hasenhuttl takes his side to the Allianz Arena for their biggest match of the season on Wednesday, and Hoeness suggested the coach could one day be a regular feature in Munich....
