Worst QB matchup: Colin Kaepernick vs. Panthers (12.2 FPPG). It could be another rough game for Kaepernick against a stingy Panthers secondary. Meanwhile, the struggling Matt Ryan has to host Seattle (12.8 FPPG to QBs).Worst WR matchup: Cecil Shorts III at Titans (14.3 FPPG). Shorts will continue to see plenty of targets with Justin Blackmon out, but this is a terrible matchup on paper. He’ll need garbage-time points, which are always in play with the Jaguars.

MORE FANTASY FOOTBALL: WR rankings | Week 10 picks | Win cash at DraftStreetWorst RB matchup: Giovani Bernard at Ravens (11.5). Not only is Bernard dealing with a rib injury, he faces the league’s stingiest defense against fantasy RBs. He could give way to BenJarvus Green-Ellis a little more often, but both backs are poor starts this weekend. Also, be wary of the Texans’ Ben Tate at Arizona (12.7 FPPG)Worst TE matchup: Coby Fleener vs. Rams (5.0 FPPG). Fleener has yet to really catch on in this offense and it’s unlikely to happen against St. Louis.Worst DEF matchup: Rams at Colts (4.4 FPPG). Andrew Luck and Co. limit mistakes and score points. It’s a bad combo for an up-and-down Rams D.Worst K matchup: Matt Bryant vs. Seahawks (3.2 FPPG). Not only is the Falcons offense sputtering without its top receivers or a formidable run game, Bryant also draws the worst kicker matchup of the week.